T Off Men's Health

What Are Common Side Affects Of Testosterone Treatment?

T Off Your Health clinics are primary care clinics that specialize in testosterone therapy for men, weight loss and allergy testing and treatment. There are three convenient locations around DFW; Uptown Dallas, Keller/Southlake and Downtown Fort Worth.

Our Treatment Plan

We have created a treatment plan for patients who are diagnosed with low testosterone to help them bring their hormone levels to healthy levels and maintain them while feeling your best. The test itself is fast and simple. Once we have established that a patient does have low testosterone we then start treatment which consists of weekly injections in the clinic. During these weekly visits patients have the opportunity to discuss any questions with one of our experienced providers. This gives the patient the best level of care.

Starting Treatment

If you are a new patient, just starting TRT it may take some time to notice significant differences in your health. Patients have reported that it took 2 months of regular appointments before they really started to experience a difference in their energy levels, mood, sleep and body. In the beginning as your body is adjusting to the new substance you are injecting weekly changes may start to occur. These changes may have you asking questions wondering what is going on and if it is “working”. During these first visits it is very important to ask questions when you have the opportunity. No question is stupid or unwelcome. If you are noticing changes and are wondering if it is “normal” and especially if you have questions or concerns be sure to speak up. Different patients experience different side effects and some side effects can be every easily managed.

Possible Common Side Effects

Side effects are possible with any drug, testosterone is no exception. The reason for sharing this list is not to scare you but to make you aware that if any of these side effects occur while you are on testosterone treatment it is common and do not be afraid to bring them to the attention of your medical provider. Each individual is exactly that, an individual and may experience different reactions. Our team is here to help you understand what is happening in your body and help you correct it if necessary. Relieving the side effect may be as simple as a change in dosage, a prescription, a referral to a specialists or if it is sever enough (which is extremely rare) discontinue treatment.

As you read through the list notice the percentages listed at 1-10% or 0.1 to 1%, indicting that though these side effects are recorded they are still affecting very few patients.


The most frequently reported side effects with this drug are edema, acne, site pain, injection site erythema, cough or dyspnea during or immediately after injection.

The most frequently reported side effects with testosterone topical are skin reaction (16.1%) and allergic contact dermatitis (up to 37%).[Ref]


Very common (10% or more): Testosterone topical: Skin reaction (16.1%), burn-like blisters (12%), itching, allergic contact dermatitis (up to 37%)

Common (1% to 10%): Acne, induration, burning


Common (1% to 10%): Fatigue, hyperhidrosis; chills, body pain, smell disorder

Uncommon (0.1% to 1%): Breast induration, breast pain, sensitive nipples, gynecomastia, increased estradiol, increased testosterone, asthenia, night sweats


Very common (10% or more): Accelerated growth

Common (1% to 10%): Increased estradiol, hypogonadism


Very common (10% or more): Testosterone buccal film: Gingivitis (32.6%)

Common (1% to 10%): Diarrhea, oily stools (due to IM injection oily solvent); Testosterone topical: Gastroesophageal reflux disease, gastrointestinal bleeding, gum or mouth irritation (9.2%), taste bitter, gum pain, gum tenderness, gum edema, taste perversion


Very common (10% or more): Testosterone topical: Application site pruritus (up to 37%), application site blistering (12%)

Common (1% to 10%): Injection site pain, injection site discomfort, injection site pruritus, erythema, injection site hematoma, injection site irritation, injection site inflammation; injection site reaction; Topical testosterone: Application site erythema, application site warmth, application site irritation, application site vesicles, application site exfoliation, application site burning, application site induration, bullae at application site, mechanical irritation at application site, rash at application site, contamination of application site


Common (1% to 10%): Hot flush, hypertension


Common (1% to 10%): Polycythemia, hematocrit increased

Uncommon (0.1% to 1%): Increased red blood cell count, increased hemoglobin, prolonged activated partial thromboplastin time, prolonged prothrombin time


Common (1% to 10%): Weight increased, appetite increased, fluid retention (sodium, chloride, water, potassium, calcium, and inorganic phosphates)

Uncommon (0.1% to 1%): Increased glycosylated hemoglobin, hypercholesterolemia, increased triglyceride

Nervous system

Common (1% to 10%): Headache, vertigo (topical testosterone)

Uncommon (0.1% to 1%): Migraine, tremor, dizziness


Common (1% to 10%): Back pain, hemarthrosis (testosterone topical)

Uncommon (0.1% to 1%): Arthralgia, pain in extremity, muscle spasm, muscle strain, myalgia, musculoskeletal stiffness, increased creatine phosphokinase


Common (1% to 10%): Prostatic specific antigen (PSA) increased, prostate cancer


Common (1% to 10%): Irritability, insomnia, mood swings, aggression,

Uncommon (0.1% to 1%): Depression, emotional disorder, restlessness, increased libido, decreased libido


Now that you have read through the list do you have any questions? If you suffer from low testosterone you know that the benefits far out weight the side effects, but if you are experiencing so side effects, be sure to address them during your next appointment. There may be an easy fix to get you feeling your best. We are here to support your highest levels of health.

Information cited from a neutral informational site Drugs.com https://www.drugs.com/sfx/testosterone-side-effects.html